Optogenetic control of striatal dopamine release in rats
نویسندگان
چکیده
منابع مشابه
Local control of striatal dopamine release
The mesolimbic and nigrostriatal dopamine (DA) systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson's and Huntington's disease, schizophrenia and addiction. Control of DA release in the striatum is tightly linked to firing of DA neurons in the ventral tegmental area (VTA) and the substa...
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Recent animal experiments suggest that transplanted neurons become integrated with the host brain. Neuroanatomical studies have shown that transplanted dopaminergic neurons can form synaptic connections on target cells in the host striatum. Other studies also have shown that grafted neurons not only innervate the host striatum but also receive afferent inputs from neurons of the host. However, ...
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The mechanisms of dopamine (DA) release central nerve endings have been investigated utilizing superfused rat striatal synaptosomes. Nomifensine was selected as a tool to discriminate between release mediated by the DA carrier and release occurring independently of the carrier. The following conclusions can be drawn from the results obtained: 1) Alterations of the sodium gradient across the syn...
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This study with monkeys was designed to answer two questions. 1) Does acute nicotine preferentially release more dopamine in the striatum than in the prefrontal cortex? 2) Do repeated doses of nicotine produce sensitization of striatal dopamine release? Microdialysis techniques were used to measure extracellular dopamine in both brain regions in two separate groups of conscious animals. The acu...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2010
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2010.06850.x